Cardiac MRI for the Detection of Myocardial Injury Following Acute Kidney Injury

University Hospital Bonn (UKB)

Status: Unknown

Conditions: Acute Kidney Injury; Cardio-Renal Syndrome; Cardiomyopathies

Treatments: Diagnostic Test: Cardiac magnetic resonance scan

Study type: Observational

Funder types: Other

Identifiers

NCT05034588

519/20

Details and patient eligibility

About

The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay by multiparametric cardiac MRI.

Full description

The aim of the study is to demonstrate any differences in myocardial structure and function using multiparametric cardiac MRI in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay and subsequent convalescence compared to a control group with intensive care stay but without kidney injury. Furthermore, the correlation between clinical disease severity and cardiac involvement will be investigated.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. acute kidney injury and convalescence (GFR > 45 ml/min/1.73m²).
2. patients who are 18 years of age or older

Exclusion criteria

1. underlying cardiac disease, e.g. known myocardial infarction, previous myocarditis, congenital heart disease, cardiomyopathies of other causes
2. known underlying disease wit potential cardiac involvement, e.g. storage disease (e.g. hemochromatosis, Fabry disease), inflammatory (e.g. sarcoidosis), endocrinological (e.g. diabetes mellitus, hyper-/hypothyroidism), autoimmune (e.g. systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis), therapeutic (chemotherapy).
3. patients with persistent renal failure and GFR < 45 ml/min/1.73m²
4. allergy to contrast media
5. patients who are using a intrauterinpessare for contraception
6. pregnant and breastfeeding women
7. patients with contraindications for MRI due to implants

Trial design

40 participants in 2 patient groups

Intensiv care patients after acute kidney injury

Description:

Patients with condition after intensive care stay and acute kidney injury and subsequent convalescence (without preexisting underlying cardiac disease or other disease with potential cardiac involvement).

Treatment:

Diagnostic Test: Cardiac magnetic resonance scan

Intensiv care patients without kidney injury

Description:

Patients with condition after intensive care stay and subsequent convalescence (without kidney injury and preexisting underlying cardiac disease or other disease with potential cardiac involvement).

Treatment:

Diagnostic Test: Cardiac magnetic resonance scan