Cardiac Performance Evaluation in Children With Steroid Dependent vs Steroid Resistant Nephrotic Syndrome

Sohag University

Status: Enrolling

Conditions: Nephrotic Syndrome

Treatments: Device: Tissue Doppler imaging and Conventional Echocardiography

Study type: Interventional

Funder types: Other

Identifiers

NCT06622915

soh_med_24_07_03MS

Details and patient eligibility

About

nephrotic syndrome (NS) is one of the most common pediatric kidney diseases There is an increased incidence of heart disease in patients with primary nephrotic syndrome (PNS) compared to the normal population Conventional Echocardiography is usually utilized to diagnose myocardial dysfunction. Tissue Doppler imaging is a non-invasive cardiac imaging technique which measures the velocity of the longitudinal motion of the mitral annulus, tricuspid annulus and the basal part of interventricular septum

Enrollment: 60 estimated patients

Sex: All

Ages: 2 to 14 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children with primary nephrotic syndrome.

  • Age: 2 - 14 years.
  • Both males and females

Exclusion criteria

• Patients of primary cardiac diseases (e.g., congenital or rheumatic heart disease, cardio- myopathy).

Patients who refuse to give written informed consent to study

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

group A,

Active Comparator group

Description:

steroid dependent nephrotic syndrome

Treatment:

Device: Tissue Doppler imaging and Conventional Echocardiography

Group B

Active Comparator group

Description:

steroid resistant nephrotic syndrome

Treatment:

Device: Tissue Doppler imaging and Conventional Echocardiography