Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery (RECOVER)

Hochgebirgsklinik Davos

Status: Enrolling

Conditions: Arrhythmia; ACS (Acute Coronary Syndrome); Cardiac Rehabilitation; CABG; Valve Anomalies; Cardiac Arrest (CA); Heart Failure; Heart Transplantation; LVAD (Left Ventricular Assist Device)

Study type: Observational

Funder types: Other

Identifiers

NCT07096973

2024-02560

Details and patient eligibility

About

The RECOVER study, titled Cardiac Rehabilitation Cohort at the Medicine Campus Davos for Exploration of Recovery, is a prospective, non-interventional, monocentric cohort study conducted at the Hochgebirgsklinik Davos. The study is sponsored by Medicine Campus Davos AG and the Kühne Foundation, with an estimated start date in July 2025 and planned completion by December 2034, with the possibility of extension.

The principal investigator of the study is PD Dr. David Niederseer from Hochgebirgsklinik Davos, who also represents the study. The research team includes co-investigators such as Prof. Dr. Stefan Blankenberg and Prof. Dr. Andreas Ziegler from Cardio-CARE, Medicine Campus Davos, as well as Dr. Jan Vontobel from Hochgebirgsklinik Davos.

The study will enroll patients referred to Hochgebirgsklinik Davos for cardiac rehabilitation who provide informed consent. Cardiac rehabilitation is an evidence-based therapy for patients with heart disease, including those who have undergone cardiac procedures or surgeries.

The primary objectives are to evaluate baseline patient characteristics, rehabilitation strategies, predictors of recovery, and clinical outcomes during and after rehabilitation. To support this, a detailed database and biobank will be established to allow for comprehensive phenotyping, extensive clinical assessments, and long-term follow-up.

RECOVER seeks to gain translational insights into how patient-specific factors - such as genetics, plasma, digital and clinical biomarkers, and comorbidities - influence long-term clinical outcomes. The goal is to identify modifiable risk factors to optimize individualized therapeutic approaches in cardiac rehabilitation.

Enrollment: 10,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing CR at the HGK
• Written informed consent
• Age ≥ 18 years

Exclusion criteria

• Insufficient knowledge of the German language to understand study documents, the interview, or questionnaires interview without translation
• Physical or psychological incapability to participate in the study