Cardiac Uptake of Metformin, Visualized by Positron Emission Tomography

Henrik Wiggers

Status and phase: Completed; Phase 1

Conditions: Heart Failure, Systolic

Treatments: Radiation: 11C-metformin

Study type: Interventional

Funder types: Other

Identifiers

NCT03122769

2016-003453-15

Details and patient eligibility

About

The purpose of the study is to evaluate if metformin is taken up into the failing myocardium. Recent experimental and epidemiological studies have shown beneficial effects of metformin on heart failure. It is unknown whether this effect is direct or indirect.

The aim of the study is to investigate if metformin is taken up in heart failure using a novel 11C-metformin tracer and positron emission tomography (PET).

Enrollment: 6 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with chronic heart failure, Left Ventricular Ejection Fraction <45%
• New York Heart Association (NYHA) class I, II, III
• Relatively preserved renal function (eGFR > 30 ml/min)
• Ability to understand the written patient information and to give informed consent
• Negative p-HCG for women of childbearing potential

Exclusion criteria

• Known allergy to metformin
• Age < 18 years
• Current abuse of alcohol or drugs

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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6 participants in 1 patient group

11C-metformin

Experimental group

Description:

All participants allocated to the study will be included in this arm

Treatment:

Radiation: 11C-metformin