CardioInsight 1 RBBB (CardioInsight1)

The Chinese University of Hong Kong

Status: Enrolling

Conditions: Heart Failure

Treatments: Device: Electrical Activation Mapping Guided Cardiac resynchronization therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05555966

2017.316

Details and patient eligibility

About

Cardiac resynchronization therapy (CRT) is an established therapy for symptomatic heart failure patients. However, there are still 30 to 40% of studied patients being nonresponder to CRT. The plausible reasons of lack of effect of CRT in these patients include relative less baseline electrical dyssynchrony. The aim of our study is to investigate whether there is an optimal configuration of CRT delivery that varies between patients with different pattern of activation delay.

Enrollment: 93 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult (aged 18 or above) of both sexes
• Ischemic or non-ischemic cause of heart failure
• QRS duration > 120 ms, non-left bundle branch block (LBBB) type of conduction disturbance
• NYHA class III or above
• Informed consent by the patient
• Already received stable dose of guideline directed medical therapy for at least 3 months

Exclusion criteria

• LBBB patients
• Pregnant women
• Participation in another study
• Patient with contraindication to left ventricle catheterization by a retrograde aortic approach

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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93 participants in 1 patient group

Tailor-made CRT delivery

Experimental group

Description:

Device placement based on Electrical Activation Mapping result

Treatment:

Device: Electrical Activation Mapping Guided Cardiac resynchronization therapy