Cardiometabolic Effects of Aerobic Exercise Plus Breaking Sitting

Yasin Ak

Status: Completed

Conditions: Sedentary Behaviour; Sedentary Time

Treatments: Other: Aerobic exercise+2 minutes of walking breaks every 30 minutes; Other: Aerobic exercise+6.5 h of prolonged sitting; Other: Aerobic exercise+8 minutes of walking breaks every 2-h; Other: Aerobic exercise+4 minutes of walking breaks every 1-h

Study type: Interventional

Funder types: Other

Identifiers

NCT06106464

LIPA Break

Details and patient eligibility

About

The goal of this randomized crossover clinical trial is to investigate the effects of interrupting prolonged sitting with intermittent walks of equal volume but at different frequencies, in addition to moderate-intensity aerobic exercise, on postprandial serum lipid profile in young adults between the ages of 18-30. The main questions it aims to answer are:

• Do interrupting prolonged sitting with intermittent walks of equal volume but at different frequencies sustain positive cardiometabolic effects after moderate-intensity aerobic exercise?
• If "yes", which frequency of breaks is more effective to provide cardiometabolic benefits?

Participants will complete four conditions on separate days: 1) 6.5 hours of prolonged sitting after 30 minutes of moderate intensity aerobic exercise 2) breaking prolonged sitting with 2 minutes of walking every 30 minutes after 30 minutes of moderate intensity exercise 3) breaking prolonged sitting with 4 minutes of walking every 1-h after 30 minutes of moderate intensity exercise 4) breaking prolonged sitting with 8 minutes of walking every 2-h after 30 minutes of moderate intensity aerobic exercise.

Enrollment: 14 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being between the ages of 18-30
• Being able to participate in physical activity
• More than 7 hours of daily sitting time measured subjectively
• Not exercising regularly in the last 3 months

Exclusion criteria

• Hypertension
• Coronary heart disease
• Heart failure
• Diabetes mellitus
• Metabolic syndrome
• Obesity
• Hypothyroidism
• Non-alcoholic fatty liver disease
• Chronic inflammatory joint disease
• Chronic renal failure
• Cushing's syndrome
• HIV infection
• Being on antihypertensive medication
• Being on lipid-lowering medication
• Being on antidiabetic medication
• Being on systemic glucocorticoid medication
• LDL-cholesterol≥130 mg.dL-1
• HDL-cholesterol <40 mg.dL-1 for men; <50 mg.dL-1 for women
• Prediabetes
• Alcohol addiction
• Smoking
• Pregnancy

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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14 participants in 4 patient groups

Aerobic exercise+6.5 h of prolonged sitting

Experimental group

Description:

Participants will sit 6.5 hours after 30 minutes of moderate intensity aerobic exercise.

Treatment:

Other: Aerobic exercise+6.5 h of prolonged sitting

Aerobic exercise+2 minutes of walking breaks every 30 minutes

Experimental group

Description:

Participants will break prolonged sitting with 2 minutes of walking every 30 minutes after 30 minutes of moderate intensity aerobic exercise.

Treatment:

Other: Aerobic exercise+2 minutes of walking breaks every 30 minutes

Aerobic exercise+4 minutes of walking breaks every 1-h

Experimental group

Description:

Participants will break prolonged sitting with 4 minutes of walking every 1-h after 30 minutes of moderate intensity aerobic exercise.

Treatment:

Other: Aerobic exercise+4 minutes of walking breaks every 1-h

Aerobic exercise+8 minutes of walking breaks every 2-h

Experimental group

Description:

Participants will break prolonged sitting with 8 minutes of walking every 2-h after 30 minutes of moderate intensity aerobic exercise.

Treatment:

Other: Aerobic exercise+8 minutes of walking breaks every 2-h