CArdioMetabolism and Atherosclerotic PlaqUe progreSsion (CAMPUS)

Shanghai Jiao Tong University

Status: Enrolling

Conditions: Coronary Artery Disease; Dyslipidemias; Obesity; Diabetes Mellitus, Type 2; Metabolic Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT05117424

RJH-CAMPUS

Details and patient eligibility

About

Systematic metabolic diseases are closely related to prevalence and progression of atherosclerosis. This prospective cohort consecutively enrolls patients with coronary artery disease compliacted with metabolic abnormalities such as diabtetes, prediabetes, obesity, chronic kidney disease and hyperuricemia.

Full description

CArdioMetabolism and Atherosclerotic PlaqUe progreSsion (CAMPUS) study is a single center, prospective cohort study to investigate the impact of cardiometabolic factors on coronary diseases. This study consecutively enrolls patients with coronary artery diseases complicatied with metabolic abnormalities, including diabetes, prediabetes, obesity, chronic kidney disease and hyperuricemia.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-80 years

• Established coronary artery disease or metabolic disorders, including:

  1. Type 2 diabetes diagnosed by one of the following criteria:

     HbA1c >/= 6.5% Fasting plasma glucose >/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT >/= 11.1 mmol/l Already receiving glucose-lowering agents

  2. Prediabetes

  3. Obesity

  4. Chronic kidney disease

  5. Hyperuricemia

  6. Dyslipidemia

Exclusion criteria

• Severe liver failure (Child-Pugh grade B to C)
• Severe anemia (hemoglobin < 60g/L)
• Familial hypercholesterolemia
• Active malignant tumor
• Active autoimmune diseases on corticosteroids
• Acute or chronic infection
• Life expectancy < 1 year