Cardioprotective Effects of Green Tea Versus Maté Intake

Instituto de Cardiologia do Rio Grande do Sul

Status and phase: Unknown; Phase 3

Conditions: Inflammation; Obesity; Dyslipidemia

Treatments: Dietary Supplement: Green tea; Dietary Supplement: Apple tea; Dietary Supplement: Yerba Mate Tea

Study type: Interventional

Funder types: Other

Identifiers

NCT00933647

Projeto Chimarrão

Details and patient eligibility

About

The investigators aim to study the effects of green tea and maté consumption on lipid and inflammatory profiles in dyslipidemic and overweight subjects.

Full description

Recommendations of lifestyle and dietary content changes are often made for primary prevention and improvement of many health conditions, including cardiovascular disease. For centuries, green tea (Camellia sinensis) has been linked to good health. Nowadays, it is considered a functional food because of its physiological benefits, mainly in terms of cardiovascular prevention. Green tea is considered one of the best sources of phenolic compounds, which possess antioxidant properties that may contribute to a reduction in the risk of cardiovascular disease. Lesser-known worldwide, but widely consumed in southern Latin America countries, yerba mate tea (Ilex paraguariensis) is also a good source of phenolic compounds. The antioxidant capacity of green tea has been extensively studied; however, few studies have reported that the antioxidant properties of maté tea is even greater than green tea. For this reason, the present study aims to compare the possible effects of the oral ingestion of maté and green tea on the lipid and inflammatory profiles in a southern Brazilian population.

Enrollment: 195 estimated patients

Sex: All

Ages: 35 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 35-60 years
• non-treated dyslipidemia (TC > 200mg/dL and/or TG > 150 mg/dL and/or HDL-c < 40 mg/dL for men and 50mg /dL for women)
• BMI 25-35 Kg/m²

Exclusion criteria

• use or indication for use of lipid-lowering agents and/or vitamin supplement
• non-steroids anti inflammatory use
• hormone replacement therapy
• contraceptive use
• pregnancy
• nursing
• unexplained weight loss (>2 Kg) 2 months before the study
• altered hepatic function
• those who do not sign the informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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195 participants in 3 patient groups, including a placebo group

Yerba Mate Tea

Experimental group

Description:

Subjects will drink 1000ml/day of yerba mate tea for 8 weeks.

Treatment:

Dietary Supplement: Yerba Mate Tea

Green Tea

Active Comparator group

Description:

Subjects will drink 1000ml/day of green tea for 8 weeks.

Treatment:

Dietary Supplement: Green tea

Apple Tea

Placebo Comparator group

Description:

Subjects will drink 1000ml/day of apple tea for 8 weeks.

Treatment:

Dietary Supplement: Apple tea