Cardiopulmonary Effects of Intrathoracic Pressure Overshoot During Carbon Dioxide Insufflation in Thoracoscopic Surgery

Army Medical University of People's Liberation Army

Status: Completed

Conditions: Esophageal Neoplasms

Treatments: Device: Insufflation of carbon dioxide (CO2)

Study type: Interventional

Funder types: Other

Identifiers

NCT02330536

QMao

Details and patient eligibility

About

Video-assisted thoracoscopic surgery (VATS) has become a standard technique for addressing all types of thoracic pathology. Insufflation of carbon dioxide (CO2) into the operated chest cavity could increase lung collapse and improve surgical field view. The actual thoracic pressure values may not be identical with the presetting on the insufflator display. This overshoot pressure during VATS may compromise cardiac and pulmonary function. The purpose of this study is to evaluate the effects of intrathoracic pressure overshoot during two-lung ventilation on the hemodynamic and respiratory function and clarify the relative safety of two different techniques of insufflation.

Enrollment: 232 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) Physical Status Ⅰ,Ⅱ
• Patients with esophageal carcinoma
• Elective video-assisted thoracic surgery

Exclusion criteria

• Allergic to drugs used in the study
• Refusal of VAST
• Arrhythmia or treated with antiarrhythmic drug
• Surgery type were converted to thoracotomy,
• Massive intraoperative blood loss (> 400ml)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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232 participants in 2 patient groups

Flowrate A

Experimental group

Description:

insufflation of carbon dioxide at 8L/min, 8mmHg

Treatment:

Device: Insufflation of carbon dioxide (CO2)

Flowrate B

Experimental group

Description:

insufflation of carbon dioxide at 20 L/min, 8mmHg

Treatment:

Device: Insufflation of carbon dioxide (CO2)