Cardiorenal and Metabolic Effects of Nighttime Eating

Koc University Hospital

Status: Completed

Conditions: Cardiorenal Syndrome; Sleep Disorder; Night Eating Syndrome; Metabolic Syndrome

Treatments: Other: Dietary

Study type: Interventional

Funder types: Other

Identifiers

NCT06588088

2022.093.IRB1.039

Details and patient eligibility

About

In this study, the investigators are trying to find out of the effect of nighttime eating on metabolism, cardiorenal, hormonal and circadian rhythm, and a study was conducted to examine the effects of diseases that are quite common in internal medicine practice, such as type 2 diabetes mellitus, chronic kidney disease, hypertension, metabolic syndrome and sleep disorders.

Full description

The Coronavirus Disease (COVID)-19 pandemic, which emerged in recent years, has deeply affected living conditions and has had an impact on societies on eating habits. As shown by some studies, it has been shown that night sleep habits have changed and night nutrition and calorie intake have increased due to reasons related to staying at home, working remotely, and isolation during the pandemic period. However, some recent studies have shown a relationship between nighttime eating and conditions that predispose to metabolic syndrome, such as obesity and hyperglycemia. At the same time, prospective studies on the details of the cardiorenal and metabolic effects of night feeding behavior, which is one of the important predisposing factors for metabolic syndrome, are quite insufficient. Although the importance of nighttime eating habits has begun to be emphasized in recent years with recent randomized cross-controlled studies on this subject, there are not yet enough prospective studies on this subject. In this respect, studies on nighttime eating behavior, which is common in society, are important.In this study, a cross-over design study was conducted on the effectiveness of nighttime eating on metabolism, cardiorenal, hormonal and circadian rhythm, and a study was conducted to examine the effects of diseases that are quite common in internal medicine practice, such as type 2 diabetes mellitus, chronic kidney disease, hypertension, metabolic syndrome and sleep disorders. The investigators aim to create a new and additional perspective on the management, treatment and follow-up of common diseases and to contribute to raising awareness about night nutrition.

Enrollment: 16 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being between the ages of 18-65
• Being willing to adapt to the desired feeding time and calories
• Body mass index (BMI) is between 18-30
• Not having any systemic disease, not using chronic medication

Exclusion criteria

• -<18, >65 years old
• Failure to comply with the regulated nutrition program
• BMI between <18 and >30
• Presence of systemic disease: E.g. Diabetes Mellitus, Chronic Kidney Disease, Coronary Artery Disease, Hypertension etc.
• Inability to have polygraphy
• Chronic drug use

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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16 participants in 2 patient groups, including a placebo group

Early eaters

Placebo Comparator group

Description:

The diet of these healthy volunteers was such that no calories were consumed after 19.30 in the evening in the first week of the study.

Treatment:

Other: Dietary

Night time Eaters

Active Comparator group

Description:

The diet of the same healthy volunteers was 25% of the daily calorie need calculated according to the Harris - Benedict formula was taken, taking into account the night time eating syndrome (NES) criteria, after 20.30 in the evening.

Treatment:

Other: Dietary