Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltration (CRUF)

Ghent University Hospital (UZ)

Status and phase: Completed; Phase 3

Conditions: Acute Decompensated Heart Failure

Treatments: Procedure: ultrafiltration; Drug: diuretics

Study type: Interventional

Funder types: Other

Identifiers

NCT01138683

2009/539

2009-017589-22 (EudraCT Number)

Details and patient eligibility

About

The CRUF trial is a prospective randomized monocentric trial comparing different impact of diuretics versus ultrafiltration on renal congestion, plasma refill rate, echocardiographic filling pressures, neurohormonal activation and biomarkers of Acute Kidney Injury (AKI).

Enrollment: 1 patient

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• >18 years old

• Severe systolic heart failure with ejection fraction <40%

• And Hospitalisation for decompensated heart failure

• And New York Heart Association (NYHA) III or IV

• And 1 of the following:

  • Jugular vein distension>6cm
  • Tissue Doppler mitral annulus lateral>12 or medial>15
  • Chest X-ray: pulmonary edema or pleural effusion

Exclusion criteria

• Need for inotropic or vasopressive agents
• Use of intravenous (IV) contrast media
• Acute coronary syndrome
• Need of dialysis
• Severe co-morbidity
• Contra-indications for anticoagulation
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1 participants in 2 patient groups

ultrafiltration group

Active Comparator group

Treatment:

Procedure: ultrafiltration

diuretics group

Active Comparator group

Treatment:

Drug: diuretics