Cardiorespiratory Fitness in Prediabetic,Type 2 Diabetic and Healthy Individuals

Hacettepe University

Status: Completed

Conditions: Inflammation; Prediabetic State; Exercise Test; Diabetes Mellitus, Type 2; Cardiorespiratory Fitness

Treatments: Diagnostic Test: Cardiorespiratory Fitness

Study type: Observational

Funder types: Other

Identifiers

NCT03823664

GO 17/793

Details and patient eligibility

About

The aim of this study to investigate and compare cardiorespiratory fitness (CRF) parameters of prediabetic, type 2 diabetic and healthy individuals. CRF assessed with cardiopulmonary exercise test (CPET) which is gold standard measure of CRF. Pulmonary functions, inflammation, disease specific parameters such as HbA1c, fasting plasma glucose etc affect CRF in prediabetic and type 2 diabetics.All parameters examine in this study.

Full description

This study will be participated with Type 2 diabetic,prediabetic and healthy patients. Patients' laboratory values, pulmonary function test, respiratory muscle strength, exercise capacity, physical activity level, quality of life, cardiorespiratory fitness levels will assess and record. Pulmonary function test will be assesed with CPET system, respiratory muscle strength will be evaluated with mouth pressure. Exercise capacity will be evaluated using six minute walking test, incremental shuttle walk test. And cardiorespiratory fitness will assess CPET system. Physical activity level will be evaluated trial accelerometer and International Physical Activity Questionnaire.

Enrollment: 48 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Cooperation,
• No assistance for Ambulation,
• Body Mass Index<40
• Diagnose of prediabetes/type 2 diabetes and health

Exclusion criteria

• Any cardiac problems,
• Uncontrolled hypertension,
• Any neurologic disease,
• Uncontrolled diabetes,
• Any orthopedic disease impairs walking, balance
• Any respiratory disease affects cardiorespiratory fitness

Trial design

48 participants in 3 patient groups

Type 2 Diabetic

Description:

Fasting Plasma Glucose ≥126 mg/dL (7.0 mmol/L). OR \* A1C ≥6.5% (48 mmol/mol). OR \* Patients with classic symptoms of hyperglycemia or hyperglycemic crisis, a random plasma glucose ≥200 mg/dL (11.1 mmol/L).OR\* 2-h Plasma Glucose ≥200 mg/dL (11.1 mmol/L) during oral glucose tolerance test\* \* American Diabetes As. (ADA) type 2 diabetes diagnosis criteria

Treatment:

Diagnostic Test: Cardiorespiratory Fitness

Prediabetic

Description:

Fasting Plasma Glucose 100 mg/dL (5.6 mmol/L) to 125 mg/dL (6.9 mmol/L) (Impaired Fasting Glucose)\* OR A1C 5.7-6.4% (39-47 mmol/mol)\* OR 2-h Plasma Glucose during 75-g Oral Glucose Tolerance Test 140 mg/dL (7.8 mmol/L) to 199 mg/dL (11.0 mmol/L) (Impaired Glucose Tolerance)\* \* ADA prediabetes criteria

Treatment:

Diagnostic Test: Cardiorespiratory Fitness

Healthy

Description:

Healthy glucose metabolism and according to endocrinology visit no health problems related or affect cardiorespiratory fitness and other parameters examined in this study.

Treatment:

Diagnostic Test: Cardiorespiratory Fitness