Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia

Radboud University Medical Center

Status and phase: Unknown; Phase 4

Conditions: Preeclampsia

Treatments: Drug: alpha methyldopa

Study type: Interventional

Funder types: Other

Identifiers

NCT00117546

2004-155

P05.0007L

Details and patient eligibility

About

A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values. In this study, the researchers will test that effect on the total cardiovascular balance.

Full description

This is a randomized double-blind placebo controlled cross-over study in formerly preeclamptic women with a contracted plasma volume. The researchers will test the effect of methyldopa on the cardiovascular balance and orthostatic tolerance in women with a history of preeclampsia and healthy controls.

Enrollment: 35 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primiparous
• History of preeclampsia
• Low plasma volume

Exclusion criteria

• Thrombophilia
• Hypertension
• Auto-immune disorder
• Insulin dependent diabetes mellitus

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind