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Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia

R

Radboud University Medical Center

Status and phase

Unknown
Phase 4

Conditions

Preeclampsia

Treatments

Drug: alpha methyldopa

Study type

Interventional

Funder types

Other

Identifiers

NCT00117546
2004-155
P05.0007L

Details and patient eligibility

About

A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values. In this study, the researchers will test that effect on the total cardiovascular balance.

Full description

This is a randomized double-blind placebo controlled cross-over study in formerly preeclamptic women with a contracted plasma volume. The researchers will test the effect of methyldopa on the cardiovascular balance and orthostatic tolerance in women with a history of preeclampsia and healthy controls.

Enrollment

35 estimated patients

Sex

Female

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Primiparous
  • History of preeclampsia
  • Low plasma volume

Exclusion criteria

  • Thrombophilia
  • Hypertension
  • Auto-immune disorder
  • Insulin dependent diabetes mellitus

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

Trial contacts and locations

1

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Central trial contact

M.E.A Spaanderman, MD, PhD

Data sourced from clinicaltrials.gov

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