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Cardiovascular and Neurovascular Regulation in GWI

University of Wisconsin (UW) logo

University of Wisconsin (UW)

Status

Enrolling

Conditions

Brain Blood Flow
Neurovascular Control

Treatments

Other: Sympathetic Nerve Activity
Device: MRI
Device: Transcranial Doppler Ultrasound

Study type

Observational

Funder types

Other
Other U.S. Federal agency

Identifiers

NCT04586049
Protocol Version 09/15/2021 (Other Identifier)
2019-0961
W81XWH1910381 (Other Grant/Funding Number)
A176000 (Other Identifier)
EDUC/KINESIOLOGY (Other Identifier)

Details and patient eligibility

About

Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.

Full description

Gulf War Illness (GWI) is a multi-symptom illness with unknown etiology. GWI is a leading cause of disability in Gulf War Veterans. Cognitive complaints are a common symptom of GWI, which suggests the brain is involved in the development of this condition. As Veterans age, these cognitive complaints may worsen and be compounded by the aging process. GWI may be a condition of "accelerated" brain aging. Therefore, there may be long-term consequences of GWI, and the presence of GWI may increase a person's risk for developing Alzheimer's Disease (AD) or other dementias. In comparison to other brain-related diseases such as stroke, relatively little is known about GWI and how this condition impacts the normal age-related changes in the brain.

The research aims are:

  1. To determine if Veterans with Gulf War Illness demonstrate abnormal brain blood flow regulation and autonomic dysfunction when compared with Veterans without Gulf War Illness.
  2. To determine if brain blood flow and autonomic nervous system variables in Veterans are associated with other markers of brain aging that are relevant to cognitive decline.

Enrollment

70 estimated patients

Sex

All

Ages

45 to 68 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Deployed to the Persian Gulf between 1990-1992
  • Body mass <300 lbs
  • Diagnosis of Gulf War Illness based on CMI/CDC and Kansas definitions or No diagnosis of Gulf War Illness

Exclusion criteria

  • Current or lifetime evidence of: Type II diabetes, neurological disease, cancer treatment, rheumatoid arthritis, lupus, bipolar disorder, psychotic disorders, or mood disorders with psychotic features
  • Current illicit substance use or partial remission for less than 1 year
  • Taking multiple sedatives or anticonvulsant medications
  • Currently pregnant
  • Absolute contraindications to exercise testing
  • Contraindications to MRI
  • Other significant medical conditions at investigator's discretion

Trial design

70 participants in 2 patient groups

Veterans with GWI
Description:
Veterans with GWI who served in the Gulf War between 1990 and 1992
Treatment:
Device: Transcranial Doppler Ultrasound
Device: MRI
Other: Sympathetic Nerve Activity
Veterans without GWI (Controls)
Description:
Veterans without GWI who served in the Gulf War between 1990 and 1992
Treatment:
Device: Transcranial Doppler Ultrasound
Device: MRI
Other: Sympathetic Nerve Activity

Trial contacts and locations

1

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Central trial contact

Jill N Barnes, PhD; Anna J Howery, MS

Data sourced from clinicaltrials.gov

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