Cardiovascular Benefits of Acai Polyphenols in Volunteers at Risk of Metabolic Syndrome (AF1)

University of Reading

Status: Completed

Conditions: Cardiovascular Diseases

Treatments: Dietary Supplement: Acai puree, frozen blended it with banana; Dietary Supplement: Control Macronutrient matched

Study type: Interventional

Funder types: Other

Identifiers

NCT02292329

AF1UReading

Details and patient eligibility

About

The purpose of this study is to carry out a randomized double blind controlled trial in 30 male subjects to investigate the effect of acai consumption on acute changes in vascular function, and to other cardiovascular markers. As a secondary aim the study will allow us to characterize the absorption and metabolism of acai polyphenols in humans over a 24 hour period.

Enrollment: 23 patients

Sex: Male

Ages: 30 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male, 30-65 aged, BMI 25-35 kg/m2, Cholesterol <8 mmol/l.

Exclusion criteria

• Female, BMI <25 or >35 kg/m2, Cholesterol >8mmol l-1, elevated fasting blood sugar > 6.5 mmols l-1 , elevated systolic blood pressure >150 mmHg, history of stroke or heart attack within the previous 12 months, current smoking, taking lipid lowering, blood pressure lowering or anti-blood clotting medication or taking micronutrient supplements.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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23 participants in 2 patient groups, including a placebo group

150g of acai fruit

Active Comparator group

Description:

150g of acai fruit in fruit smoothie form

Treatment:

Dietary Supplement: Acai puree, frozen blended it with banana

Placebo control

Placebo Comparator group

Description:

The control will be a smoothie-like drink matched for major macro- and micro-nutrients

Treatment:

Dietary Supplement: Control Macronutrient matched