Cardiovascular Effects of Adderall in Healthy Adults.

Mayo Clinic

Status and phase: Completed; Phase 4

Conditions: Cardiovascular System; Hemodynamics

Treatments: Drug: Placebo capsule; Drug: Adderall capsule

Study type: Interventional

Funder types: Other

Identifiers

NCT02979327

16-004743

Details and patient eligibility

About

This study is designed to investigate the cardiovascular response (blood pressure, heart rate, electrocardiographic response and blood vessel reactivity response) to taking Adderall in healthy adults.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Adults 18 years of age and older
2. Healthy subjects without known cardiovascular disease, thyroid disease or documented mental health illness
3. Subjects who are on no medications
4. Subjects with no prior history of regular amphetamine use, and non-prescription stimulants
5. Nonsmokers

Exclusion Criteria

1. Subjects with known cardiovascular disease, thyroid disease
2. Subjects with history of psychotic disorders/mental health illness, including but not limited to anxiety, depression, bipolar disorder; history of substance abuse or dependence
3. Subjects currently taking medications
4. Prior history of regular amphetamine use, or non-prescription stimulants
5. Smokers
6. Pregnant subjects
7. Known lactose intolerance (due to presence of lactose in the prepared medication)
8. Family history of sudden cardiac death

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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30 participants in 2 patient groups

Adderall first, then Placebo

Experimental group

Description:

Participants will receive an Adderall capsule at the first study visit, then a Placebo capsule at the second study visit.

Treatment:

Drug: Adderall capsule

Drug: Placebo capsule

Placebo first, then Adderall

Experimental group

Description:

Participants will receive a Placebo capsule at the first study visit, then an Adderall capsule at the second study visit.

Treatment:

Drug: Adderall capsule

Drug: Placebo capsule