Cardiovascular Effects of Sporting Events

Chinese Academy of Medical Sciences, Fuwai Hospital

Status and phase: Completed; Early Phase 1

Conditions: Coronary Heart Disease

Treatments: Behavioral: No exposure to sporting events; Behavioral: Exposure to sporting events

Study type: Interventional

Funder types: Other

Identifiers

NCT00795405

sporting events

Details and patient eligibility

About

Major sporting events may have adverse cardiovascular effects in subjects with coronary heart disease. We also hypothesized that the adverse cardiovascular effects of sporting events are a result of psychobiological processes including stress-induced hemodynamic changes, autonomic dysfunction and parasympathetic withdrawal, and inflammatory and prothrombotic responses, all of which may in turn promote myocardial ischemia.

Full description

Observational studies suggest that exposure to sporting events may worsen symptoms of angina and trigger acute myocardial infarction. The mechanisms for this association are unknown. To date, there have been no controlled exposures in patients with coronary heart disease: an important population who may be particularly susceptible to the adverse cardiovascular effects of sporting events.

In a randomized crossover controlled study, 38 patients with prior myocardial infarction will be exposed to sporting events or not. Myocardial ischemia will be quantified by ST-segment analysis using continuous 12-lead electrocardiography, and blood pressure change will be analyzed using ambulatory blood pressure monitoring. Autonomic function will be assessed by heart rate variability. Ischemic, inflammatory and prothrombotic markers will also be measured.

Enrollment: 38 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Previous myocardial infarction (>6 months previously)treated by coronary revascularization
• On standard secondary preventative therapy

Exclusion criteria

• Angina pectoris (Canadian Cardiovascular Society grade ≥2)
• History of arrhythmia
• Uncontrolled hypertension
• Unstable coronary disease (acute coronary syndrome or unstable symptoms within 3 months)
• Occupational exposure to sporting events
• Diabetes
• Hepatic or renal failure

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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38 participants in 2 patient groups

1

Sham Comparator group

Description:

No exposure to sporting events

Treatment:

Behavioral: No exposure to sporting events

2

Experimental group

Description:

Exposure to sporting events

Treatment:

Behavioral: Exposure to sporting events