Cardiovascular Events Based On Statin Initiation In The Elderly

Viatris

Status: Completed

Conditions: Dyslipidemia; Cardiovascular

Treatments: Other: Simvastatin Initiators; Other: Atorvastatin Initiators

Study type: Observational

Funder types: Industry

Identifiers

NCT01304641

A2581188

Details and patient eligibility

About

The purpose of this study is to compare rates and risk of primary cardiovascular events among elderly patients newly initiating therapy with atorvastatin or simvastatin. The specific objectives for this project are to: 1) examine the demographic and clinical characteristics of the elderly patients in whom atorvastatin or simvastatin was newly initiated; and 2) compare cardiovascular event rates in elderly patients in whom atorvastatin or simvastatin was newly initiated.

Full description

All subjects meeting sample definition, all inclusion criteria, and none of the exclusion criteria.

Enrollment: 31,603 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥ 1 fill for atorvastatin or simvastatin (not including combination therapy) between 01 July 2006 and 30 November 2008
• Age ≥ 65 years as of the year of index date
• Continuous enrollment with medical and pharmacy benefits during the analytic period

Exclusion criteria

• 1 or more fills for a statin or other dyslipidemia medication in the 12-month pre-index period
• A pharmacy fill for clopidogrel or nitrates (except concomitant hydralazine) in the 12-month pre-index period
• Patients with evidence of a cardiovascular event in the 12-month pre-index period.
• Patients who received both atorvastatin and simvastatin on the index date
• Patients with unknown gender or region
• Patients who received dyslipidemia medications other than the index drug within 1 months (30 days) following the index date

Trial design

31,603 participants in 2 patient groups

Atorvastatin Initiators

Treatment:

Other: Atorvastatin Initiators

Simvastatin Initiators

Treatment:

Other: Simvastatin Initiators