Cardiovascular Health Effects of Flavanol Rich Chocolate (CHOC)

Wageningen University

Status: Completed

Conditions: Endothelial Dysfunction

Treatments: Dietary Supplement: High fat challenge; Dietary Supplement: Low flavanol chocolate; Dietary Supplement: High flavanol chocolate

Study type: Interventional

Funder types: Other

Identifiers

NCT01308892

NL33506.081.10

Details and patient eligibility

About

In the CHOC study the investigators will examine the effect of chocolate flavanols on vascular function, inflammation, oxidative stress and markers of endothelial function. The effects of both acute consumption and prolonged consumption will be studied. The secondary objectives are to investigate if daily intake of chocolate flavanols for 4 weeks will improve the response to a high fat/high energy challenge.

Enrollment: 44 estimated patients

Sex: Male

Ages: 45 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• 45-70 years old
• BMI between 25 and 32 kg/m2

Exclusion criteria

• Urine glucose concentrations outside normal ranges (> 0,25 g/l)
• Fasting blood glucose < 7.0 mmol/L)
• Systolic Bp > 160 mmHg or diastolic Bp > 100 mmHg
• Blood Hb values below 8.4 mmol/L
• Allergic to cow milk, dairy products or chocolate
• Vegetarian
• Tobacco smoker
• Diagnosed with any long-term medical condition (e.g., diabetes, hemophilia, cardiovascular disease, anemia, gastrointestinal disease, renal failure)

Trial design

44 participants in 2 patient groups, including a placebo group

High flavaonol chocolate

Active Comparator group

Treatment:

Dietary Supplement: High fat challenge

Dietary Supplement: High flavanol chocolate

Low flavanol chocolate

Placebo Comparator group

Treatment:

Dietary Supplement: High fat challenge

Dietary Supplement: Low flavanol chocolate