Cardiovascular Imaging and Biomarker Analyses (CIBER)

Universitätsmedizin Mannheim

Status: Unknown

Conditions: Coronary Artery Disease; Heart Failure; Heart Diseases

Treatments: Diagnostic Test: computed tomography; Diagnostic Test: magnetic resonance imaging; Diagnostic Test: blood withdrawl; Diagnostic Test: Echocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT03074253

2014-615N-MA

Details and patient eligibility

About

"Cardiovascular Imaging and Biomarker Analyses (CIBER)" is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is aimed to evaluate associations with biomarker expressions with ascertained cardiac imaging parameters.

Full description

"Cardiovascular Imaging and Biomarker Analyses (CIBER)" is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is aimed to evaluate associations with biomarker expressions with ascertained cardiac imaging parameters. Furthermore the prognostic value of biomarkers and imaging parameters on mid-term and long-term prognosis will be evaluated. Novel biomarkers will comprise blood derived biomarkers including neurohormones, proteins, cytokines, microRNAs and metabolomics.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with low to intermediate risk for coronary artery disease

Exclusion criteria

• under 18 years
• mechanical heart valve
• pulmonary embolism
• deep vein thrombosis
• myocardial infarction within the last 3 months
• electrical cardioversion within 30 days
• status after heart transplant
• transient ischemic attack (TIA) or stroke within last 30 days
• intracerebral bleeding within the last 2 months
• acute infection
• existing or planned pregnancy
• chronic kidney disease with eGFR < 40 ml/min