Cardiovascular Oscillations in Coronary Patients With and Without Type 2 Diabetes

Universidade Federal de Sao Carlos

Status: Completed

Conditions: Coronary Artery Disease; Diabetes Mellitus, Type 2

Treatments: Other: Isometric exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT02050399

13287613.0.0000.5504

Details and patient eligibility

About

Coronary artery disease (CAD) and diabetes mellitus (DM) may promote alterations in heart responses during exercise or postural maneuver. Thus, the purpose of this study is to observe the influence of different postures (supine, seated and standing) and different percentages (15, 30, 45 and 60%) of the maximum voluntary contraction (MVC) of handgrip in the responses of heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV) and peripheral vascular resistance (PVR) in coronary patients with and without type 2 diabetes.

Enrollment: 30 patients

Sex: Male

Ages: 45 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• coronary artery disease
• clinical diagnosis of type 2 diabetes
• free of type 2 diabetes to participate of control group and coronary disease without Type 2 Diabetes group
• nonsmokers
• not alcoholics

Exclusion criteria

• autonomic neuropathy
• clinical exercise testing with ECG alterations (ST-segment depression greater than 2 mm, ventricular and supraventricular arrhythmias, sustained or non-sustained supraventricular tachycardia, atrial tachycardia, atrial fibrillation and atrioventricular blocks) or symptom of angina induced by stress.
• Individuals with hypertension and diabetes mellitus not controlled.
• Subjects who did not complete all assessments.
• Subjects with temporal (R-Ri and pressure) series with noise preventing the evaluation

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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30 participants in 3 patient groups

Healthy subjects

Active Comparator group

Description:

15 men, 45 and 65 years old. After initial evaluation, clinical exercise testing, cardiopulmonary exercise testing, carotid ultrasound, laboratory tests (biochemical blood) and isometric exercise protocol will be performed.

Treatment:

Other: Isometric exercise

Coronary disease with Type 2 Diabetes

Experimental group

Description:

15 men, 45-65 years old, with coronary artery disease and type 2 diabetes will perform clinical exercise testing, cardiopulmonary exercise testing, carotid ultrasound, laboratory tests (biochemical blood), clinical autonomic tests and isometric exercise protocol will be performed.

Treatment:

Other: Isometric exercise

Coronary disease without Type 2 Diabetes

Experimental group

Description:

15 men, 45-65 years old, with coronary artery disease will perform clinical exercise testing, cardiopulmonary exercise testing, carotid ultrasound, laboratory tests (biochemical blood) and isometric exercise will be performed.

Treatment:

Other: Isometric exercise