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Background:
Objectives:
Eligibility:
Design:
Full description
HIV is now a chronic infection as patients with access to antiretroviral therapy have significantly improved life expectancies. Patients with HIV also have an increased risk of cardiovascular disease. Thus, cardiovascular disease is an important potential co-morbidity for patients living with HIV. The current proposal will perform a detailed cardiovascular assessment using state-of-the-art imaging techniques to evaluate intramyocardial lipid as well as coronary artery disease and myocardial function in a cohort of 100 HIV infected patients and 30 healthy volunteers as controls. This is an early exploratory cross-sectional study designed to both assess the burden of disease and apply novel techniques in this unique population.
Enrollment
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Inclusion and exclusion criteria
INCLUSION CRITERIA:
EXCLUSION CRITERIA:
Subject is deemed unable to comply with requirements of study participation.
Subjects with contraindication to MRI scanning. These contraindications include but are not limited to the following devices or conditions:
Subjects requiring sedation for MRI studies.
Subjects with a condition precluding entry into scanner and acquisition of scans (e.g. morbid obesity, claustrophobia, back pain, motion disorders).
Women who are lactating, pregnant, or actively seeking to become pregnant.
History of severe allergic reaction to gadolinium contrast agents despite the use of premedication with an anti-histaminic and cortisone.
Estimated glomerular filtration rate (eGFR) <60 cc/min/1.73m(2).
Creatinine value >3.0 mg/dl
For Coronary CTA with Iodine-Based Contrast*:
Contraindication to the use of CT contrast agents:
Subjects with contraindication precluding the use of beta blockers necessary to perform the coronary CTA. These include:
Guidelines for use of beta blocker is outlined in Appendix 1.
Healthy Control Criteria:
INCLUSION CRITERIA:
EXCLUSION CRITERIA:
All of the exclusion criteria for HIV-infected participants listed above apply to healthy controls. In addition, the following exclusion criteria will also be applied to healthy controls:
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Data sourced from clinicaltrials.gov
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