Cardiovascular Response to Isometric BFR Exercise

The University of Texas System (UT)

Status: Completed

Conditions: Blood Pressure

Treatments: Behavioral: Isometric handgrip exercise with a narrow-elastic band; Behavioral: Isometric handgrip exercise; Behavioral: Isometric handgrip exercise with a wide-rigid cuff

Study type: Interventional

Funder types: Other

Identifiers

NCT06529068

STUDY00006378

Details and patient eligibility

About

The goal of this interventional study is to evaluate the acute impact of isometric blood flow restriction (BFR) exercise on blood pressure and other cardiovascular functions in healthy young adult volunteers. The main question it aims to answer is:

The investigators hypothesize that isometric BFR exercise with a wide-rigid cuff would lead to greater blood pressure and other cardiovascular responses and that these cardiovascular responses would be greater under isometric BFR exercise with narrow-elastic bands compared with the control condition (no cuff).

Participants will perform isometric exercises in 3 laboratory visits with different exercise conditions) no cuff control 2) BFR with wide-rigid cuff 3) BFR with narrow-elastic band.

Enrollment: 21 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Apparently healthy young adults aged between 18 - 40 years old and signed the informed consent.

Exclusion criteria

• Abnormal clotting times
• Acid-base imbalance/acidosis
• Arterial calcification
• Atherosclerotic vessels
• Cardiopulmonary conditions
• Diabetes
• Dialysis/central venous access
• General/local infection
• High intracranial pressure
• Hip, pelvis, or femur fracture
• History of venous thromboembolism
• Hypertension
• Immobility for greater than 48 hours in the past month
• Immobilizing cast
• Implanted medical device
• Lymphectomies
• Obesity
• Open fracture
• Open or unhealed soft tissue injuries
• Paralysis
• Peripheral vascular disease
• Pregnancy/postpartum
• Prior revascularization
• Renal compromise
• Severe crush injuries
• Sickle cell trait/anemia
• Skin grafts
• Stroke
• Temporary nerve damage
• Thrombophilia
• Tumor/cancer
• Varicose veins
• Vascular grafting

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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21 participants in 3 patient groups

Isometric exercise without BFR cuff (control)

Active Comparator group

Treatment:

Behavioral: Isometric handgrip exercise

Isometric exercise with narrow-elastic BFR band

Experimental group

Treatment:

Behavioral: Isometric handgrip exercise with a narrow-elastic band

Isometric exercise with wide-rigid BFR cuff

Experimental group

Treatment:

Behavioral: Isometric handgrip exercise with a wide-rigid cuff