Cardiovascular Responses in Adolescent Idiopathic Scoliosis Girls

Tung Wah College

Status: Completed

Conditions: Adolescent Idiopathic Scoliosis

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT04868331

2019-02-52-SRG190201

Details and patient eligibility

About

The aims of this pilot study are to determine the metabolic demand and exercise intensity level of E-Fit exercise intervention by evaluating the cardiovascular responses in AIS girls and whether the cardiovascular responses for AIS girls performing E-Fit will behave in the same way as compared to healthy controls. We hypothesise that 1) the metabolic demand and exercise intensity of E-Fit exercise intervention is equivalent to moderate-to-vigorous level; and 2) AIS girls have different cardiovascular responses as compared to healthy controls

Full description

AIS girls and age- and gender-matched healthy controls will perform the E-Fit exercise intervention for two trials and gas exchange parameters including oxygen consumption (VO2) and carbon dioxide production (VCO2) will be taken continuously during the exercise. Comparison of VO2 and VCO2 between AIS and healthy controls when performing E-Fit exercise will be made.

Enrollment: 20 patients

Sex: Female

Ages: 10 to 16 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Cobb angle greater or equal to 15 degree
• Cleared for physical activity by doctor

Exclusion criteria

• Cobb angle greater or equal to 40 degree, or
• Scoliosis with any known etiology, scoliosis with skeletal dysplasia, know endocrine and connective tissue abnormalities, or
• Known heart condition or other diseases that could affect the safety of exercise, or
• Eating disorders or GI malabsorption disorders, or
• Currently taking medication that affects bone or muscle metabolism

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

AIS girls

Experimental group

Description:

Girls between the ages of 10-16 will be recruited if they have a diagnosis of AIS.

Treatment:

Behavioral: Exercise

Healthy Controls

Active Comparator group

Description:

Healthy adolescent girls matched in age and puberty maturity without spinal deformity

Treatment:

Behavioral: Exercise