Cardiovascular Responses in Congestive Heart Failure With Cheyne- Stokes Respiration

ResMed

Status: Completed

Conditions: Cheyne-Stokes Respiration; Heart Failure, Congestive

Treatments: Procedure: Experimental lung function test

Study type: Interventional

Funder types: Industry

Identifiers

NCT00495196

X07-0079

Details and patient eligibility

About

The purpose of the trial is to investigate the cardiovascular response to peripheral chemoreceptor stimulation in Congestive Heart Failure with Cheyne- Stokes Respiration

Enrollment: 50 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Moderate to severe heart failure (NYHA Class II or above) on optimal medical therapy
• LVEF less than or equal to 45%
• Stable condition as defined as no hospital admission or changes to medical therapy within two weeks prior to enrolment

Exclusion criteria

• Patients taking known respiratory stimulants or depressants
• Clinically significant asthma requiring therapy
• Significant parenchymal lung disease
• Primary pulmonary hypertension
• Myocardial infarction within three months prior to enrolment
• Patients with cardiac resynchronisation devices and permanent pacemakers
• Anaemic (haemoglobin < 12g/dL)

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

1

Experimental group

Treatment:

Procedure: Experimental lung function test

2

Active Comparator group

Treatment:

Procedure: Experimental lung function test