Cardiovascular Risk After Preeclampsia

Charité University Medicine Berlin

Status: Enrolling

Conditions: Preeclampsia

Study type: Observational

Funder types: Other

Identifiers

NCT05277233

CARPE

Details and patient eligibility

About

Investigation of cardiovascular risk 5-15 years after early or late-onset preeclampsia by adenosine stress Magnetic Resonance Imaging and non-invasive methods like retinal vessel analysis, skin measurement of advanced glycation end products, flow-mediated dilation or pulse wave analysis in comparison to women after healthy pregnancies.

Enrollment: 60 estimated patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women
• 18-60 years
• 5-15 years postpartum

Exclusion criteria

• Atrioventricular block, chronic obstructive pulmonary disease, bronchial asthma
• Pregnancy and/or active breastfeeding
• Glaucoma disease, epilepsy
• In addition for MRI: metal implants, electric devices, intolerance of contrast media, claustrophobia, renal or hepatic dysfunction (GFR < 30 ml/min)

Trial design

60 participants in 3 patient groups

Early-onset preeclampsia

Description:

Defined as preeclampsia that develops before 34 weeks of gestation

Late-onset preeclampsia

Description:

Defined as preeclampsia that develops after 34 weeks of gestation

Control

Description:

Healthy pregnancies, matched to early and late-onset cases