Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation (CRAFT-CTCA)

University of Edinburgh

Status

Enrolling

Conditions

Kidney Transplant; Complications

Cardiovascular Diseases

Treatments

Radiation: Computed tomography coronary angiography (CTCA)

Study type

Observational

Funder types

Other

Identifiers

NCT06234410

TCS/22/09

Details and patient eligibility

About

Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause of death in patients following transplantation.

Current strategies to assess patient's cardiovascular risk prior to kidney transplantation do not identify those at highest risk and do not improve outcomes.

This study will use a heart scan known as computed tomography coronary angiography (CTCA) to see whether this scan can identify patients at highest risk of future cardiovascular disease prior to transplantation. Studies have shown it is able to do this in patients with normal kidney function.

The aim of this study is to develop CTCA as an effective tool to risk stratify patients prior to kidney transplantation.

Enrollment

332 estimated patients

Sex

All

Ages

16+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Has kidney failure and is on the waitlist for a kidney transplant
Age 16 years and over
Able to give informed consent

Exclusion criteria

Contraindication to CT scanning, including contrast allergy
Patients being considered for a simultaneous kidney-pancreas, kidney-liver and/or kidney-islet transplantation
Inability to give informed consent