Cardiovascular Risk Evaluation in Psoriasis Treated With Photochemotherapy

Cairo University (CU)

Status: Completed

Conditions: Psoriasis Vulgaris

Treatments: Radiation: PUVA

Study type: Interventional

Funder types: Other

Identifiers

NCT02990624

CVR in UV phototherapy

Details and patient eligibility

About

Ultraviolet (UV) phototherapy is a standard treatment for many inflammatory dermatological diseases, including psoriasis. The systemic effects of UV phototherapy are still not well studied. There are several factors that may affect patient's cardiovascular (CV) risk during UV phototherapy. Atherosclerosis is now known to have an inflammatory origin and to be frequently associated with psoriasis. In this study the investigators aim at studying the effect of psoralen-UVA phototherapy on several biomarkers of CV risk in patients with psoriasis with or without atherosclerosis.

Enrollment: 65 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Disease affecting > 10% body surface area
• Patient willing to commit to 3 sessions weekly for 3-6 months without interruption

Exclusion criteria

• Disease severity less than 10% body surface area
• Patients unable to commit for therapeutic schedule due to work or residence issues.
• pregnant and lactating females
• photosensitive dermatoses

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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65 participants in 3 patient groups

High risk group

Active Comparator group

Description:

Patients with psoriasis and atherosclerosis will receive PUVA therapy for 36 sessions divided as 3 sessions weekly

Treatment:

Radiation: PUVA

Low risk group

Active Comparator group

Description:

Patients with psoriasis but no atherosclerosis detected, will receive PUVA therapy for 36 sessions divided as 3 sessions weekly

Treatment:

Radiation: PUVA

Control group

No Intervention group

Description:

Age-matching apparently normal individuals will receive no interventions but will perform investigational tests.