Cardiovascular Risk Factors and Severe COVID-19. A Nationwide Registry-based Case-Control Study

Karolinska Institute

Status: Active, not recruiting

Conditions: COVID-19

Treatments: Other: Diabetes type 2; Other: Obesity; Other: Hypertension; Other: Chronic kidney disease; Drug: Statins (Cardiovascular Agents); Drug: Antihypertensive Agents

Study type: Observational

Funder types: Other

Identifiers

NCT04426084

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Details and patient eligibility

About

In this study we cross-reference several nationwide high-quality Swedish registers in order to study risk factors for severe Covid-19 outcomes.

Full description

In this nationwide, case-control study we cross-reference several detailed, high-quality Swedish registers in order to study risk factors associated with severe Covid-19 as well as different disease outcomes, with a focus on cardiovascular disease, chronic kidney disease, different treatments and socioeconomic factors. Cases are identified through the Swedish intensive care register (SIR) and controls through the Swedish population register (RTB). Further information on the study participants is gathered by linkage to registers on: prescribed drugs; history of in- and outpatient care; income, education and migration. Follow-up data such as future hospitalization and mortality will be gathered prospectively.

Enrollment: 22,784 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cases: Admitted to intensive care unit in Sweden and registered admission in the Swedish intensive care register (SIR) with a main diagnosis of Covid-19 confirmed by laboratory testing (ICD10: U07.1). (cases)
• Control subjects matched for age, gender,residency: For each case 10 controls matched for age, gender and district of residence will be identified by Statistics Sweden (SCB) in the Swedish population register (RTB).
• Control subjects matched for age and gender: For each case 5 controls matched for age and gender will be identified by by Statistics Sweden (SCB) in the Swedish population register (RTB).

Exclusion criteria

• No valid Swedish personal identity number (PIN)