Cardiovascular Risk in Children With Chronic Conditions Study (CR3C)

Semmelweis University

Status: Enrolling

Conditions: Chronic Kidney Disease; Aorta Stenosis; Systemic Lupus Erthematosus; Non Alcoholic Fatty Liver Disease; Type 2 Diabetes Mellitus (T2DM); Kawasaki Disease; Lymphoma; Juvenile Idiopahtic Arthritis; White Coat Hypertension; Coarctation of Aorta; Bone Marrow Transplant; Cancer (Solid Tumors); Obesity and Overweight; Transposition of Great Arteries; Inflammatory Bowel Disease (IBD); Kidney Transplant; Leukemia; Liver Transplant; Familial Hypercholesterolaemia; Hypertension; HIV Infection; Type 1 Diabetes Mellitus (T1DM); Lipoprotein(a); Pulmonary Hypertension; Dyslipaemia

Study type: Observational

Funder types: Other

Identifiers

NCT07086989

NNGYK/00994-4/2025

Details and patient eligibility

About

Children living with chronic health conditions may be at higher risk of developing heart and blood vessel problems earlier in life. Although experts recommend close monitoring, we still don't fully understand how to best predict or prevent these issues over the long term.

Recent studies suggest that tiny blood vessels (the microvasculature) can already begin to show damage many years before heart disease becomes noticeable. This early damage may be linked to ongoing inflammation, changes in metabolism, or the effects of certain treatments. However, we don't yet know how these factors affect children's blood vessels as they grow.

Our study aims to better understand what causes this increased heart risk in children with chronic conditions. We also plan to develop artificial intelligence (AI) tools that can help detect early signs of cardiovascular risk and support more personalized, proactive care.

Enrollment: 300 estimated patients

Sex: All

Ages: 6 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Individuals aged between 6 and 25 years;
2. Diagnosed with a chronic childhood condition/disease associated with an increased risk of early cardiovascular disease;
3. Provided informed consent (if over 18 years old) or had informed consent provided by their legal guardian (if under 18 years old) following appropriate information about the study.

Chronic childhood conditions/diseases associated with increased risk of early cardiovascular disease are defined according to the 2019 American Heart Association recommendations (https://doi.org/10.1161/CIR.0000000000000618), as well as other conditions/diseases for which at least two large-scale epidemiological studies have demonstrated an increased risk of cardiovascular disease.

Exclusion criteria

1. Severe intellectual and developmental disability;
2. Decompensated heart failure;
3. Severe primary immunodeficiency;
4. Ongoing intravenous chemotherapy;
5. Infectious diseases posing a public health risk; or
6. History of regular alcohol or drug use.