Cardiovascular Risk Markers in Veterans With Post Traumatic Stress Disorder (CVMarkers)

INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium

Status: Terminated

Conditions: Post Traumatic Stress Disorder; Cardiovascular Disease

Study type: Observational

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT01650220

INTRuST-CV Markers

Details and patient eligibility

About

This is an observational study designed to determine whether veterans with PTSD have a higher risk of heart disease than those without PTSD. Cardiovascular risk will be assessed by interview and review of medical records, carotid artery ultrasound, and blood tests measuring markers of inflammation. Study participation is approximately 6 months. The eligible study population is veterans of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF), age 28 through 38 years.

Enrollment: 13 patients

Sex: All

Ages: 28 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• OEF/OIF veterans at the VASDHS
• Between 28 and 38 years of age
• Willing to complete structured diagnostic interview for PTSD, CIMT ultrasound and blood test
• Willing to have a review of their medical records
• Able to give informed consent
• Have a negative urine pregnancy test, if a woman of child-bearing age

Exclusion criteria

• Do not meet inclusion criteria
• History of schizophrenia, other neurocognitive illness (including severe TBI by INTRuST criteria)) or active alcohol and/or drug abuse determined by chart review, interview or AUDIT-C score
• Inability to complete study tests within 18 months of study start
• Pregnancy

Trial design

13 participants in 2 patient groups

Veterans with a history of PTSD

Veterans without a history of PTSD