Cardiovascular Safety After Continuous Ketamine Infusion

Universidad de Antioquia

Status: Completed

Conditions: Postoperative Pain; Ketamine Adverse Reaction; Pain

Treatments: Drug: Ketamine

Study type: Observational

Funder types: Other

Identifiers

NCT03979105

UdeA1005

Details and patient eligibility

About

Observational study that evaluate the cardiovascular and neuropsychiatric side effects of ketamine analgesic infusions for acute pain

Full description

Severe acute pain and opioid tolerance is an important symptom in patients after surgery.

Ketamine in analgesic infusion has been described to decrease acute pain, in patients with opioid tolerance. Ketamine use has been associated with side effects, which are doses dependant. Those side effects are mainly cardiovascular: Hypertension, tachycardia, and neuropsychiatric: delirium, hallucinations,nightmares that potentially compromise recovery of patients.

Objective:

To determine retrospectively in data bases the frequency of tachycardia, hypertension, delirium, hallucinations and nightmares, in adult patients that received ketamine infusions before and after administration of this drug in the first 48 hours to treat acute and postoperative pain

Enrollment: 300 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 18 years old
• Acute and Postoperative pain
• Ketamine infusion at 0.15 mg/kg/h or below

Exclusion criteria

• Cognitive disfunction psychiatric illness
• Acute cardiovascular disease
• Anemia with Hb less than 7 g/dl
• Decompensated hyperthyroidism
• Low cardiac output
• Incomplete medical history

Trial design

300 participants in 1 patient group

Ketamine infusion

Description:

Ketamine infusion treatment for acute pain in adult population in all type of surgery that received adjuvant analgesia with ketamine 0.1mg/kg/h during 48 hours.

Treatment:

Drug: Ketamine