Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Cataplexy; Narcolepsy

Treatments: Device: Polysomnography

Study type: Observational

Funder types: Other

Identifiers

NCT02913651

1600111

Details and patient eligibility

About

Autonomic nervous system dysfunction has been described in narcolepsy with cataplexy affecting the sympathetic function. In this study the investigators analyzed whether altered diurnal and nocturnal cardiovascular control is present in idiopathic hypersomnia. Drug-free patients diagnosed with idiopathic hypersomnia and age-matched controls were included. Clinical data, 24-h polysomnography, heart rate variability and the heart rate response to spontaneous arousal are analyzed.

Enrollment: 33 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Idiopathic hypersomnia patients

• idiopathic hypersomnia diagnosis
• complaints of excessive daytime sleepiness for >1 year
• a night-time length >10 h for 3 weeks before polysomnography as assessed by a sleep diary

Inclusion Criteria:

no idiopathic hypersomnia patients

• no sleep complaints and excessive daytime sleepiness (Epworth sleep questionnaire score <10

Exclusion Criteria (both):

• Narcolepsy-cataplexy
• sleep irregularities and sleep deprivation symptoms
• lack of neurological or psychiatric diseases
• upper airway resistance syndrome
• periodic limbs movements
• cerebral lesion
• medication or drinks affecting sleep and wake state

Trial design

33 participants in 2 patient groups

Idiopathic hypersomnia

Description:

Drug-free patients diagnosed with idiopathic hypersomnia from 01/01/11 to 15/09/15

Treatment:

Device: Polysomnography

Controls

Description:

Patients with no sleep complaints, having a 24-h ambulatory ad libitum polysomnography

Treatment:

Device: Polysomnography