Caribbean Island Urinary Iodine Survey 2018 (CRUISE)

Federal Institute of Technology (ETH) Zurich

Status: Completed

Conditions: Iodine Deficiency

Study type: Observational

Funder types: Other

Identifiers

NCT04388540

CRUISE

Details and patient eligibility

About

Many of the Caribbean island nations have no data on iodine status in their populations.

Iodine deficiency in children can reduce IQ but can be easily corrected through a program of salt iodization.

The study will be located at 11 islands of the Caribbean region. At each of the 11 study sites, we will measure the iodine status in school-age children by collecting morning spot urine samples for measurement of urinary iodine concentration (UIC). We will also measure height and weight in all children. We will collect a repeat, next-day spot urine sample in 1/3rd of children to adjust for intra-individual variation in spot UIC and calculate the distribution of population intake.

Full description

In well-controlled randomized trials in Europe and New Zealand, even mild-to-moderate iodine deficiency in school-age children reduces IQ (1); thus, its critical to avoid iodine deficiency in this age group. In countries effected by iodine deficiency, its sustainable elimination through iodized salt can contribute to socioeconomic development. The goal to eliminate iodine deficiency was first adopted globally at the World Summit for Children in 1990, and in 1994, WHO and UNICEF concluded that salt iodization is a safe, cost-effective and sustainable strategy to control iodine deficiency (2). In 2005, the World Health Assembly called on national governments to report on their iodine nutrition every three years. However, before the present survey, the ten countries included in this project had no data on iodine status in their populations, and household access to adequately iodized salt was also unknown. Thus, the study objectives were:

• Assess the distribution of iodine intake of school-age children and their iodine status by measuring urinary iodine concentrations;
• Assess the iodine content of household salt and of seasoning powders;
• Based on the above, provide the preliminary evidence base on which to make initial recommendations for iodine strategy/programs in the region.

Enrollment: 3,080 patients

Sex: All

Ages: 6 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. age at study enrolment 6 to 12 years
2. healthy; no known history of major medical illnesses and taking no chronic medications;
3. residence at the respective study site for 12 months or longer;
4. no use of iodine containing dietary supplements during the last 6 months;
5. no use of X-ray / CT contrast agent or iodine containing medication within the last year.

Trial design

3,080 participants in 10 patient groups

Jamaica

Description:

School aged children 6 - 12 years living in Jamaica

Trinidad and Tobago

Description:

School aged children 6 - 12 years living in Trinidad and Tobago

Belize

Description:

School aged children 6 - 12 years living in Belize

Barbados

Description:

School aged children 6 - 12 years living in Barbados

St. Lucia

Description:

School aged children 6 - 12 years living in St. Lucia

Grenada

Description:

School aged children 6 - 12 years living in Grenada

St. Vincent & the Grenadines

Description:

School aged children 6 - 12 years living in St. Vincent \& the Grenadines

Antigua

Description:

School aged children 6 - 12 years living in Antigua

Dominica

Description:

School aged children 6 - 12 years living in Dominica

St. Kitts and Nevis

Description:

School aged children 6 - 12 years living in St. Kitts and Nevis