Carnitine Supplementation and Bone Mineral Density

Poznan University of Physical Education

Status: Completed

Conditions: Osteoporosis

Treatments: Dietary Supplement: L-leucine; Dietary Supplement: L-carnitine

Study type: Interventional

Funder types: Other

Identifiers

NCT05120011

BW2021/RO

Details and patient eligibility

About

The primary aim of the current research project is to explore whether carnitine supplementation and resistance training may prevent decrements in bone mineral density of aged women.

A secondary aim of this project is to investigate the effect of supplementation on body composition and blood markers.

Full description

The study includes postmenopausal women. The subjects participate in resistance training (twice a week) for each session consisted of 6 exercises: horizontal seated leg press, seated chest press, leg extension, shoulder press, lat pull-down seated row, seated cable row.

During the 24-weeks training programme participants are supplemented by carnitine with leucine, or leucine alone (placebo).

Enrollment: 36 patients

Sex: Female

Ages: 60 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• postmenopausal
• lack of restrictions to perform resistance exercises

Exclusion criteria

• cardiovascular disease
• liver disease
• kidney disease
• neuromuscular disease
• gastrointestinal disorders (including stomach ulcers and erosions)
• diabetes
• other severe chronic diseases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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36 participants in 2 patient groups, including a placebo group

carnitine + leucine

Experimental group

Description:

1000 mg L-carnitine with 3000 mg L-leucine per day for 24 weeks

Treatment:

Dietary Supplement: L-carnitine

Dietary Supplement: L-leucine

leucine

Placebo Comparator group

Description:

4000 mg L-leucine per day for 24 weeks

Treatment:

Dietary Supplement: L-leucine