Carnitine Supplementation and Skeletal Muscle Function

G

Gdansk University of Physical Education and Sport

Status and phase

Completed
Phase 3

Conditions

Sarcopenia

Treatments

Dietary Supplement: carnitine
Dietary Supplement: placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT02692235
2014/15/B/NZ7/00893

Details and patient eligibility

About

Research project objectives The primary aim of the current research project is to use carnitine supplementation as the anti-inflammatory intervention for exploring the relationship between inflammation and associated with aging reduction of skeletal muscle mass. Hypothesis The carnitine supplementation modulates the blood cytokines concentration. Anti-inflammatory intervention delay the reduction of skeletal muscle mass associated with aging

Full description

Volunteers over 65 years old (n=40) are supplemented either with carnitine or placebo for 24 weeks. Before the start, in the mid-point, and after finishing the supplementation the following primary outputs variables are performed: body composition analysis (InBody720), maximal isokinetic knee extensor peak torque (Biodex System 4 Pro), blood cytokines and carnitine concentration, blood lipid profile.

Enrollment

28 patients

Sex

All

Ages

65 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Subjects with no history of gastrointestinal disorders, cardiovascular disease or hypertension.

Exclusion criteria

  • Subjects having any illnesses and a history of gastrointestinal disorder, cardiovascular disease, hypertension, liver and renal disease, diabetes, cancer, alcoholism or other metabolic diseases.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

28 participants in 2 patient groups, including a placebo group

carnitine
Experimental group
Description:
24 weeks l-carnitine-l-tartrate supplementation
Treatment:
Dietary Supplement: carnitine
placebo
Placebo Comparator group
Description:
24 weeks isonitrogenous supplementation
Treatment:
Dietary Supplement: placebo

Trial documents
2

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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