Carotenoid Response to the Intake of Vegetables and Fruits

USDA Grand Forks Human Nutrition Research Center

Status: Completed

Conditions: Resonance Raman Spectroscopy for Dietary Carotenoid Intake

Treatments: Other: Carotenoid Repletion; Other: Natural Repletion; Other: Carotenoid Depletion

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT01403844

GFHNRC022

Details and patient eligibility

About

The purpose of this study is to validate the non-invasive tool, resonance Raman spectroscopy for assessing vegetable and fruit consumption.

Full description

This study will validate the use of resonance Raman spectroscopy to assess vegetable and fruit intake by performing a controlled feeding study during which volunteers will consume a provided diet with known amounts of carotenoids in the form of fruits and vegetables.

Enrollment: 29 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men and women aged 18 - 65 years
• Weight stable (±5 lbs) for at least 2 months prior to the start of the study
• Body mass index (BMI) between 19-30 kg/m2
• Willing to refrain from the use of nicotine and dietary supplements for the duration of the study
• Willing to maintain baseline weight and physical activity levels

Exclusion criteria

1. BMI greater than 30.
2. Gastrointestinal disorders, disease, or medication that affects carotenoid absorption or storage
3. Current smoker
4. Allergies or intolerances to foods to be utilized in the study
5. Consumption of greater than an average of 1 alcoholic drink/day for women and 2/day for men, use of nutritional/sports supplements (if unwilling to discontinue during the study)
6. Pregnancy or lactating

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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29 participants in 1 patient group

Skin Carotenoids

Other group

Description:

Skin carotenoids will be measured under conditions of depletion or repletion

Treatment:

Other: Carotenoid Repletion

Other: Natural Repletion

Other: Carotenoid Depletion

Other: Carotenoid Depletion