Carotid Arteries Stenting Complications: Transradial Approach Versus Transfemoral

Meshalkin Research Institute of Pathology of Circulation

Status: Completed

Conditions: Stroke; Carotid Atherosclerosis; Carotid Stenosis; Ischemic Attack; Bleeding

Treatments: Procedure: Transfemoral carotid artery stenting; Procedure: Transradial carotid artery stenting

Study type: Interventional

Funder types: NETWORK

Identifiers

NCT02722720

CASTE-1.0

Details and patient eligibility

About

The aim is to compare the safety of using transfemoral and transradial approach in patient undergoing carotid arteries stenting.

Full description

The use of transradial approach in carotid arteries stenting can significantly decrease the amount of adverse events associated with transfemoral approach such as bleeding or hematoma. Otherwise providing transradial approach is fraught with technical difficulties of common carotid artery canulation that can result in embolic complications. Taking into account the absence of studies in this area of medicine, providing investigation evaluating parameters of safety for both methodics is very actual.

Enrollment: 200 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Symptomatic patients with internal carotid artery stenosis(>50%)
• Asymptomatic patients with internal carotid artery stenosis(>60%)
• Anatomy of internal carotid artery applicable for stent implantation and use of embolic protection device

Exclusion criteria

• Stroke, myocardial infarction or underwent operative treatment within 1 month
• Prior carotid artery stenting
• Cerebral vessels aneurisms/ malformations
• Subclavian artery/ brachiocephalic trunk stenosis
• Contraindications for antiplatelet or/and anticoagulation therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

200 participants in 2 patient groups

Carotid stenting, Transradial approach

Experimental group

Description:

Internal carotid artery stenting using transradial arterial approach

Treatment:

Procedure: Transradial carotid artery stenting

Carotid stenting, Transfemoral approach

Active Comparator group

Description:

Internal carotid artery stenting using transfemoral arterial approach

Treatment:

Procedure: Transfemoral carotid artery stenting