Carotid Artery Stent Implantation in the Treatment of Vulnerable Plaque (CASTLE)

Beijing Tsinghua Chang Gung Hospital

Status: Enrolling

Conditions: Carotid Artery Plaque; Carotid Stenosis; Stent Embolisation

Treatments: Procedure: carotid artery stenting

Study type: Observational

Funder types: Other

Identifiers

NCT05524207

20220816

Details and patient eligibility

About

To investigate the efficacy and safety of carotid stenting for vulnerable carotid plaques. All patients with carotid artery stenosis underwent carotid arterial contrast-enhanced ultrasonography before operation. According to the examination results, they were divided into two groups: vulnerable plaque group and stable plaque group. The incidence of perioperative stroke events in the two groups was compared. The incidence of stroke events in the two groups within 1 year was compared.

Full description

1. To enroll 100 cases of patients suffering from carotid artery stenosis。the investigators perform contrast enhanced ultrasound on patients for identifying the vulnerable plagues
2. The investigators divide patients into the stable group and the vulnerable group based on the results of CEUS inspection.
3. All patients undergo carotid stent. To analysis the incidence of postoperative complications such as stroke and mortality within 30 days and to compare the differences between the two groups.

Enrollment: 100 estimated patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patients with ischemic symptom whose carotid stenosis were more than 50%
• The patients without ischemic symptom whose carotid stenosis were more than 70%

Exclusion criteria

• • Confirmed with severe intracranial vascular lesions

  • Suffering from the large area cerebral infarction or critical stroke sequela
  • Restenosis after CEA or CAS
  • Suffering from severe coronary heart disease, respiratory failure,the hypertension difficult to controled
  • Patients with malignant tumor or expected life < 2 years

Trial design

100 participants in 2 patient groups

Vulnerable plaque group

Description:

Patients with preoperative contrast-enhanced intra-plaque contrast agent were classified as vulnerable plaque group

Treatment:

Procedure: carotid artery stenting

Stable plaque group

Description:

The patients with no contrast agent enhancement in the plaque showed preoperative contrast-enhanced ultrasound were classified as stable plaque group

Treatment:

Procedure: carotid artery stenting