Carotid Atherosclerotic Disease Following Childhood Scalp Irradiation

Shamir Medical Center (Assaf-Harofeh)

Status: Completed

Conditions: Atherosclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT00590421

Car&RAD05

57/04

Details and patient eligibility

About

Background: During the first half of the 20th century, scalp irradiation was a standard treatment for induction of epilation in children suffering from Tinea Capitis. These children are now more than 50 years old and the aim was to investigate the possible association between their childhood low dose irradiation exposure and development of carotid atherosclerotic disease in adulthood.

Methods: The study included 145 individuals treated by irradiation in their childhood, and 150 matched control subjects with no history of irradiation. B-mode ultrasound imaging and US Doppler were used to measure carotid and femoral stenosis and Intima-Media Thickness (IMT). Blood samples were taken for lipid profile and homocysteine evaluation.

Enrollment: 295 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18 or older
• childhood scalp irradiation or mach controls
• writen informed consent

Exclusion criteria

• inability to give written informed consent

Trial design

295 participants in 2 patient groups

1

Description:

145 individuals treated by irradiation in their childhood

2

Description:

150 matched control subjects with no history of irradiation