Carotid Intima-media Thickness as Cardiovascular Mortality Predictor in Peritoneal Dialysis Patients

Istanbul University

Status: Completed

Conditions: Myocardial Infarction

Study type: Observational

Funder types: Other

Identifiers

NCT02938767

3221

Details and patient eligibility

About

Cardiovascular (CV) disease is the main cause of death in patients on dialysis. The aim of this study is the long-term prognostic values of carotid intima-media thickness and coronary flow reserve in cardiovascular mortality of peritoneal dialysis patients.

Full description

Endothelial dysfunction (ED) is a precursor and cause of cardiovascular diseases. Defining of endothelial thickness and coronary microvascular function could be useful for detecting ED. Endothelial dysfunction could be assessed by coronary flow reserve (CFR), carotid intima media thickness (IMT). Repeating measurement of IMT and CFR could be predictor of cardiovascular events and mortality in peritoneal dialysis patients.

Enrollment: 57 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Peritoneal dialysis patients whose followed up at least six months from October 1994 to October 2011 (for study group)
• Kidney transplant recipients whose followed up at least six months from October 1994 to October 2011 (for control group)

Exclusion criteria

• diabetes mellitus
• valvular heart disease,
• any prior coronary intervention and congestive heart failure
• Patients whose left anterior descending coronary artery (LAD) could not be visualized adequately by Doppler echocardiography were also excluded.

Trial design

57 participants in 2 patient groups

peritoneal dialysis patients

Description:

37 peritoneal dialysis patients followed at the Istanbul Medical Faculty from October 1994 to October 2011

renal transplant recipients

Description:

20 renal transplant recipients followed at the Istanbul Medical Faculty from October 1994 to October 2011 setted as the control group