Carpal Tunnel Syndrome and Amyloidosis (AMICAR)

Corporacion Parc Tauli

Status: Unknown

Conditions: Carpal Tunnel Syndrome; Amyloidosis

Treatments: Procedure: Carpal tunnel syndrome surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT04245098

CSPT_AMICAR1

Details and patient eligibility

About

Carpal tunnel syndrome has been suggested to be an early sign of amyloidosi. The investigators will evaluate tissue samples obtained from patients undergoing carpal tunnel release surgery for amyloid.

Full description

Carpal tunnel syndrome (CTS) can be caused by the deposition and accumulation of misfolded proteins called amyloid and is often an early manifestation of systemic amyloidosis.

Patients with cardiac amyloidosis often have carpal tunnel syndrome that precedes cardiac manifestations by several years, and many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand.

The investigators sought to identify the prevalence and type of amyloid deposits in patients undergoing carpal tunnel surgery and evaluate for cardiac involvement

Enrollment: 100 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing carpal tunnel syndrome surgery

Exclusion criteria

• None

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Amyloid

Experimental group

Description:

Biopsy

Treatment:

Procedure: Carpal tunnel syndrome surgery