Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Epilepsy

Treatments: Other: functional MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT03102957

38RC09.21

Details and patient eligibility

About

Exploring the reorganization (plasticity) of neuroanatomic networks associated with language and memory in patients with left (or dominant hemisphere) temporal lobe epilepsy using functional MRI (fMRI)

Full description

The purpose of this study is to explore the reorganization of neuroanatomic networks associated with language and memory in adult patients with temporal lobe epilepsy (ELT). By using functional MRI, patients will be examined before and after surgery. Cerebral plasticity, defined in terms of intrinsic variables such as the topography of the activated regions, will be explored according to some extrinsic factors such as the age at onset of crises (before or after 5-6 years), whether or not Hippocampal sclerosis, hemispheric predominance of language (left or right).

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• epileptic patients
• medical exam before inclusion
• social security affiliation
• Pharmaco-resistant epilepsy

Exclusion criteria

• MRI contraindication
• pregnant women
• breastfeeding mothers
• person under tutorship

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

epileptic patients

Experimental group

Description:

2 functional MRI (pre and post resective surgery) with memory and language tasks

Treatment:

Other: functional MRI

Healthy volunteers

Other group

Description:

1 functional MRI with memory and language tasks

Treatment:

Other: functional MRI