Castration-resistant Prostate Cancer and Intra-prostatic Hormonal Status (HORM)

Hopital Foch

Status: Withdrawn

Conditions: Prostate Cancer

Treatments: Procedure: Trans-rectal biopsy; Biological: intra-prostatic concentration of sexual steroids

Study type: Interventional

Funder types: Other

Identifiers

NCT03014973

2016/03

2016-A00020-51 (Other Identifier)

Details and patient eligibility

About

The main objective of the study is to determine the intra-prostatic concentration of sexual steroids when castration resistance appears in castration-resistant prostate cancer patients compared to patients naif of hormonal treatment

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• group 1: patients with a locally advanced prostate cancer naif of any hormonal treatment
• group 2: Patients with a castration-resistant prostate cancer resisting defined by a biological progression
• group 2a: without radiotherapy
• group 2b: with radiotherapy
• Affiliated to a social security scheme
• Having given a written consent.

Exclusion criteria

• Patient unable to supply a written consent (patient not understanding French, under guardianship patient).
• neuro-endocrine form or sarcomatoid form prostate cancer

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

prostate cancer patients resistant to castration

Experimental group

Treatment:

Biological: intra-prostatic concentration of sexual steroids

Procedure: Trans-rectal biopsy

patients naif of hormonal treatment

Experimental group

Treatment:

Biological: intra-prostatic concentration of sexual steroids

Procedure: Trans-rectal biopsy