Catecholamine Blockade Post-burn

Sunnybrook Health Sciences Centre

Status: Unknown

Conditions: Burns

Treatments: Drug: placebo; Drug: propranolol

Study type: Interventional

Funder types: Other

Identifiers

NCT01299753

Propran_Jeschke

Details and patient eligibility

About

Severe burn is associated with a wide array of stress, metabolic, and physiologic processes in an attempt to restore homeostasis. The catecholamine induced stress response following severe burns is particularly exaggerated and manifests detrimentally as inflammation, insulin resistance, hypermetabolism, and associated profound protein catabolism. The investigators hypothesize that catecholamine blockade will lead to restored IR signaling and result in improved post-burn morbidity. The investigators will further determine the molecular mechanisms mediating these effects.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients between 18 and 90 years of age
• >25% TBSA burn

Exclusion criteria

• Death upon admission
• Decision not to treat due to burn injury severity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups, including a placebo group

Control

Placebo Comparator group

Treatment:

Drug: placebo

Beta blockade

Experimental group

Treatment:

Drug: propranolol