Catestatin and Hypertension in Pregnancy

Yuchen Pan

Status: Unknown

Conditions: Pre-Eclampsia; Hypertension, Pregnancy-Induced; Hypertension in Pregnancy; Eclampsia

Study type: Observational

Funder types: Other

Identifiers

NCT03200743

20170513

Details and patient eligibility

About

Catestatin is a kind of protein involved with cardiovascular disease. Accumulated evidence shows that Catestatin may be a predictor of primary hypertension, but whether it plays the same role in pregnant hypertensive disorders needs to be determined. By measuring the plasma level of Catestatin, main biochemical marks and UCG in healthy pregnancy and pregnancy with hypertension, the research may contribute to this problem.

Enrollment: 400 estimated patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy pregnancy women

• Pregnancy women with hypertension

  1. Despite the pregnant gestational age , systolic blood pressure ≥140 mm Hg OR a diastolic blood pressure of ≥90 mm Hg measured three times more than 24 hours apart
  2. Pregnant gestational age > 20 weeks, systolic blood pressure ≥140 mm Hg OR a diastolic blood pressure of ≥90 mm Hg measured twice more than 4 hours apart

Exclusion criteria

• Lack of blood sample at the specified enrollment period
• Women who refuse the study
• Other illness which needs medications interfering with blood pressure (eg: Asthma requiring systemic steroids)
• Known coronary artery disease or heart failure
• Serious medical illness (eg: renal insufficiency, congestive heart disease, chronic respiratory insufficiency, uncontrolled infection).
• multiple endocrine neoplasia or Cushing's syndrome or mixed tumours or pheochromocytoma or medullary thyroid carcinoma.
• previous history of malignant tumour, with the exception of carcinoma in situ of the uterine cervix or non-melanoma skin cancer
• renal insufficiency

Trial design

400 participants in 2 patient groups

Hpertension

Health