Catheter Ablation of Arrhythmias to Improve CRT Response (ABLATE-CRT)

Kansas City Heart Rhythm Institute

Status and phase: Terminated; Phase 4

Conditions: Arrhythmia, Cardiac

Treatments: Drug: Anti-Arrhythmics; Procedure: Catheter Ablation

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03035227

STUDY00003861

Details and patient eligibility

About

The purpose of this study is to test if catheter ablation is better than medication therapy at treating arrhythmias originating from the upper and/or lower chambers of the heart in order to allow the heart to beat properly.

Enrollment: 2 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Heart failure patients with CRT-D or CRT-P greater than 3 months
• Bi-ventricular pacing less than 94% of the time
• 3 months after CRT-D or CRT-P implantation an EF improvement less than 5%
• Presence of one of the following arrhythmias and eligible for catheter ablation:
• Atrial fibrillation
• Atrial flutter
• Supraventricular tachycardia
• Premature ventricular contraction burden greater than 30% in a 24-hour period
• Ventricular tachycardia

Exclusion criteria

• Estimated survival less than one year
• Patient unable to make scheduled follow up visits at treating center
• Participating in another investigational study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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2 participants in 2 patient groups

Catheter Ablation

Active Comparator group

Description:

Catheter ablation procedure of atrial and/or ventricular arrhythmias.

Treatment:

Procedure: Catheter Ablation

Medical Therapy

Active Comparator group

Description:

Medical management using antiarrhythmic drugs per standard of care of treating physician.

Treatment:

Drug: Anti-Arrhythmics