Catheter Ablation Versus Antiarrhythmic Drugs for Outflow Tract Ventricular ARrhythmias (AVATAR)

San Donato Group (GSD)

Status and phase: Unknown; Phase 4

Conditions: Ventricular Premature Complexes; Ventricular Tachycardia

Treatments: Drug: antiarrhythmic drugs (Flecainide or Propafenone or Sotalol); Procedure: Catheter Ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT01780311

Arezzo008

Details and patient eligibility

About

A randomized, parallel, open study comparing catheter ablation versus antiarrhythmic drugs for outflow tract ventricular arrhythmias

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. presence of ventricular ectopic beats (VEB) with left-bundle-branch block morphology or right-bundle-branch block morphology and positive concordance throughout the chest leads, inferior axis and at least one of the following:

2. >2000 isolated VEB/24h

3. symptomatic monomorphic ventricular tachycardia

4. left ventricular disfunction supposed to be due to tachycardia-induced cardiomyopathy

Exclusion criteria

1. known structural heart disease
2. pregnancy
3. life expectancy < 1 year

Trial design

0 participants in 2 patient groups

Antiarrhythmic drugs

Active Comparator group

Description:

Flecainide or Propafenone or Sotalol (oral, standard dosage)

Treatment:

Drug: antiarrhythmic drugs (Flecainide or Propafenone or Sotalol)

ABLATION

Experimental group

Description:

Catheter Ablation

Treatment:

Procedure: Catheter Ablation