Catheter Ablation Versus Medical Treatment of AF in Heart Failure (CAMTAF)

Barts & The London NHS Trust

Status: Unknown

Conditions: Atrial Fibrillation; Heart Failure

Treatments: Drug: Medical treatment alone; Procedure: Catheter ablation of persistent atrial fibrillation

Study type: Interventional

Funder types: Other

Identifiers

NCT01411371

05/Q0605/47

Details and patient eligibility

About

Heart failure and atrial fibrillation (AF) often coexist, and each increases the morbidity and mortality associated with the other. The investigators hypothesized that restoration of normal sinus rhythm by catheter ablation is superior to medical treatment of AF in heart failure. This study randomizes patients with heart failure and persistent AF to medical treatment of AF or catheter ablation to restore sinus rhythm.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Persistent atrial fibrillation
• Symptomatic heart failure

Exclusion criteria

• Reversible causes of heart failure
• Contraindications to catheter ablation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Catheter Ablation

Experimental group

Description:

Catheter ablation of persistent atrial fibrillation to restore normal sinus rhythm.

Treatment:

Procedure: Catheter ablation of persistent atrial fibrillation

Medical treatment alone

Active Comparator group

Description:

Patients are randomised to medical treatment alone for atrial fibrillation. Treatment will be as per current guidelines for persistent atrial fibrillation, with rate control as first line (using beta-blockers, calcium channel blockers and digoxin as indicated) and rhythm control as second line (using sotalol, dronedarone, or amiodarone as indicated). (Both groups will receive standard heart failure medication including angiotensin converting enzyme inhibitors, beta blockers, aldosterone antagonists, and diuretics as indicated).

Treatment:

Drug: Medical treatment alone