Catheter-interventional Treatment of Pulmonary Embolism (CATCH-PE)

Heart Center Leipzig - University Hospital

Status: Completed

Conditions: Pulmonary Embolism

Treatments: Device: combined catheter-thrombectomy and local fibrinolysis; Other: conventional treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT05456789

CATCH-PE

Details and patient eligibility

About

Recent evidence supports the use of catheter-interventional techniques for the treatment of intermediate-high-risk pulmonary embolism. While there is evidence supporting the use of catheter-thrombectomy and alternatively local fibrinolysis, less is known on the combination of both approaches.

The investigators aim to assess the effects of a combined interventional local fibrinolysis and catheter-thrombectomy and to compare them with conventional treatment in a cohort of patients with intermediate-high-risk pulmonary embolism.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• confirmed intermediate high-risk pulmonary embolism
• age >= 18 years

Exclusion criteria

• high-risk pulmonary embolism
• contraindications for catheter-based treatment
• known allergy to anticoagulant treatment or fibrinolytics
• pregnancy
• participation in other randomized trials
• patients under legal supervision or guardianship

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Combined interventional treatment

Experimental group

Description:

Combined catheter-based fibrinolysis and thrombectomy plus conventional treatment

Treatment:

Device: combined catheter-thrombectomy and local fibrinolysis

conventional treatment

Active Comparator group

Description:

Conventional treatment

Treatment:

Other: conventional treatment